D.9.2+Drug+Design


 * D.9.2 Explain the use of combinatorial and parallel chemistry to synthesize new drugs**


 * Combinatorial Chemistry**
 * Used to synthesize a large number of different compounds.
 * Produces an electronic database or combinatorial library.
 * The initial compound that demonstrates biological activity is called a lead compound, and is systematically modified to produce more effective derivatives.
 * Used to mass produce drugs by two solid-phase synthesis.

Solid-phase synthesis or mix and split:
 * starting material is covalently bonded to small polystyrene beads
 * beads are reacted with one another and then split and reacted with new substances to make new combination of molecules
 * produced a wide range of molecules
 * the products are then purified by filtering of the beads and washing
 * Used to build proteins (polypeptides)
 * This method is fully automated and uses robotics


 * Parallel synthesis**
 * Used to produce smaller, more focused libraries